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Migraine Space

Migraine anxiety & depression cycle: CGRP inhibitors help break it?

Migraine anxiety & depression cycle: CGRP inhibitors help break it?

From Head Start's Annual Meeting, January 2025

The January 2025 Head Start webinar explored the UNITE study, A multi-centre, double-blind, placebo-controlled, parallel-group, clinical trial followed by an open-label extension to evaluate the efficacy and safety of fremanezumab for the preventive treatment of migraine in patients with Major Depressive Disorder. This study was designed to assess patients with migraine and comorbid depressive disorder to demonstrate the potential of anti-CGRP addressing migraine and psychiatric comorbidities in a complex patient populations.1

Discover the key insights from the UNITE study in this Head Start webinar! Listen to the short video led by Dr Giorgio Lambru as he explains the outcomes resulting in significant reductions in migraine days, improvements in depression scores, and strong tolerability—showing the potential of anti-CGRP therapy to transform care for complex cases. Watch now to explore the migraine anxiety & depression cycle: CGRP inhibitors help break it?

Resources

Sleep Disorders and Headache
Education & Events Featured

Sleep Disorders and Headache

Dr Alexander Nesbitt provides an overview of sleep-related headache disorders

Behavioural change for migraine prevention
Education & Events

Behavioural change for migraine prevention

Professor Ivo Vlaev discusses the application of behavioural science in migraine prevention

Cracking complex cases: complexities of comorbidities in headache
Education & Events

Cracking complex cases: complexities of comorbidities in headache

Complexities of comorbidities in headache with Dr David Moreno and Dr Maria Villar-Martinez

Practical management of migraine and comorbid depression and anxiety
Education & Events

Practical management of migraine and comorbid depression and anxiety

Dr Sophie White and Elizabeth Shaw share real-world strategies to help you manage migraine patients with depression and anxiety.

Understanding the burden of migraine on the NHS
Education & Events

Understanding the burden of migraine on the NHS

Bethany Hill and Elizabeth Akinsanya discuss how migraine prevention can ease NHS pressure and improve outcomes.

Care closer to home – headache service redesign to bring care into the community
Education & Events

Care closer to home – headache service redesign to bring care into the community

Anne-Marie Logan discusses headache service redesign to bring care into the community

Managing migraine patients’ unmet need today
Education & Events

Managing migraine patients’ unmet need today

Susie Lagrata and Claire Fisher deliver a nurse-led masterclass on unmet needs in migraine care

Extra disclaimers:

* AJOVY® (fremanezumab) is not indicated for the treatment of comorbid major depressive disorder

References:

  1. Lipton RB et al. JAMA Neurol. 2025; 82(6):560-569

Abbreviations:

CGRP, calcitonin gene-related peptide

Date of Preparation: January 2026 | D: MIG-GB-00990 / T: MIG-GB-00994 / M: MIG-GB-00995
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